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The effect of co-processed dry binder with microcrystalline cellulose on release of verapamil hydrochloride from hydrophilic matrix tablets

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F18%3A39913360" target="_blank" >RIV/00216275:25310/18:39913360 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11160/18:10382391

  • Result on the web

    <a href="http://dx.doi.org/10.32383/appdr/85701" target="_blank" >http://dx.doi.org/10.32383/appdr/85701</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.32383/appdr/85701" target="_blank" >10.32383/appdr/85701</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The effect of co-processed dry binder with microcrystalline cellulose on release of verapamil hydrochloride from hydrophilic matrix tablets

  • Original language description

    The aim of this study was to evaluate the use of co-processed dry binder MicroceLac100 (lactose and microcrystalline cellulose in ratio 3 : 1) and Comprecel 102 (pure microcrystalline cellulose) in formulations for the extended release of verapamil hydrochloride. Hydrophilic matrix tablets containing verapamil hydrochloride, hypromellose and dry binder were prepared by the direct compression method. Hypromelloses MethocelTM K4M Premium CR or MethocelTM K100M Premium CR were used as controlled release agents. Using scanning electron microscopy regular distribution of the active substance in the prepared tablets was confirmed. Release of verapamil hydrochloride from the prepared formulations was studied by the dissolution test method. The dissolution profiles were fitted to the first-order kinetic model, Higuchi diffusion model, Korsmeyer-Peppas and Weibull model and kinetic parameters as the first order release rate constant (k1), release exponent (n) from Korsmeyer-Peppas model, Higuchi constant (KH) and parameters of Weibull model (b, λ) were determined. Based on the results of non-linear regression analysis, the higher release rate constants were found for formulations containing co-processed dry binder MicroceLac100 in comparison with formulations containing pure microcrystalline cellulose (Comprecel 102). In addition, tablets swelling, erosion and disintegration during the dissolution test were monitored photographically.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Acta Poloniae Pharmaceutica - Drug Research

  • ISSN

    0001-6837

  • e-ISSN

  • Volume of the periodical

    75

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    PL - POLAND

  • Number of pages

    9

  • Pages from-to

    1223-1231

  • UT code for WoS article

  • EID of the result in the Scopus database

    2-s2.0-85056238070