A study of the combination of microcrystalline cellulose and mannitol in a co-processed dry binder and in a physical mixture for the use in orally disintegrating tablets
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F19%3A39915240" target="_blank" >RIV/00216275:25310/19:39915240 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/19:10399482
Result on the web
<a href="https://ptfarm.pl/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/28055" target="_blank" >https://ptfarm.pl/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/28055</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.32383/appdr/102487" target="_blank" >10.32383/appdr/102487</a>
Alternative languages
Result language
angličtina
Original language name
A study of the combination of microcrystalline cellulose and mannitol in a co-processed dry binder and in a physical mixture for the use in orally disintegrating tablets
Original language description
Avicel® HFE-102 is a co-processed dry binder containing 90% microcrystalline cellulose and 10% mannitol. This paper compares this co-processed dry binder and a physical mixture of related dry binders, microcrystalline cellulose (Avicel® PH-102) and mannitol (Pearlitol® 100SD) in the ratio of 9 : 1. Flow properties, compressibility, lubricant sensitivity, tensile strength, friability and disintegration time of tablets are evaluated. Compressibility is evaluated by means of the energy profile of compression process, and lubricant sensitivity by means of the lubricant sensitivity ratio. The results are also compared with the microcrystalline cellulose for direct compression Avicel® PH-102 alone. The flow properties of the co-processed dry binder Avicel® HFE-102 alone and the physical mixture were comparable. Avicel® HFE-102 showed higher values of the energy of plastic deformation, tensile strength of tablets, and a markedly lower lubricant sensitivity and tablet friability than the physical mixture of dry binders. Addition of lubricants exerted different effects on the disintegration of tablets. The co-processed excipient AvicelÆ HFE-102 is suitable for the use in orally dispersible tablets.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Poloniae Pharmaceutica - Drug Research
ISSN
0001-6837
e-ISSN
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Volume of the periodical
76
Issue of the periodical within the volume
2
Country of publishing house
PL - POLAND
Number of pages
11
Pages from-to
355-365
UT code for WoS article
000468126500017
EID of the result in the Scopus database
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