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A study of the combination of microcrystalline cellulose and mannitol in a co-processed dry binder and in a physical mixture for the use in orally disintegrating tablets

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F19%3A39915240" target="_blank" >RIV/00216275:25310/19:39915240 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11160/19:10399482

  • Result on the web

    <a href="https://ptfarm.pl/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/28055" target="_blank" >https://ptfarm.pl/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/28055</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.32383/appdr/102487" target="_blank" >10.32383/appdr/102487</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    A study of the combination of microcrystalline cellulose and mannitol in a co-processed dry binder and in a physical mixture for the use in orally disintegrating tablets

  • Original language description

    Avicel® HFE-102 is a co-processed dry binder containing 90% microcrystalline cellulose and 10% mannitol. This paper compares this co-processed dry binder and a physical mixture of related dry binders, microcrystalline cellulose (Avicel® PH-102) and mannitol (Pearlitol® 100SD) in the ratio of 9 : 1. Flow properties, compressibility, lubricant sensitivity, tensile strength, friability and disintegration time of tablets are evaluated. Compressibility is evaluated by means of the energy profile of compression process, and lubricant sensitivity by means of the lubricant sensitivity ratio. The results are also compared with the microcrystalline cellulose for direct compression Avicel® PH-102 alone. The flow properties of the co-processed dry binder Avicel® HFE-102 alone and the physical mixture were comparable. Avicel® HFE-102 showed higher values of the energy of plastic deformation, tensile strength of tablets, and a markedly lower lubricant sensitivity and tablet friability than the physical mixture of dry binders. Addition of lubricants exerted different effects on the disintegration of tablets. The co-processed excipient AvicelÆ HFE-102 is suitable for the use in orally dispersible tablets.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10403 - Physical chemistry

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Acta Poloniae Pharmaceutica - Drug Research

  • ISSN

    0001-6837

  • e-ISSN

  • Volume of the periodical

    76

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    PL - POLAND

  • Number of pages

    11

  • Pages from-to

    355-365

  • UT code for WoS article

    000468126500017

  • EID of the result in the Scopus database