A study of a novel coprocessed dry binder composed of alpha-lactose monohydrate, microcrystalline cellulose and corn starch
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F17%3A10364556" target="_blank" >RIV/00216208:11160/17:10364556 - isvavai.cz</a>
Result on the web
<a href="http://www.tandfonline.com/doi/full/10.3109/10837450.2015.1131717" target="_blank" >http://www.tandfonline.com/doi/full/10.3109/10837450.2015.1131717</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10837450.2015.1131717" target="_blank" >10.3109/10837450.2015.1131717</a>
Alternative languages
Result language
angličtina
Original language name
A study of a novel coprocessed dry binder composed of alpha-lactose monohydrate, microcrystalline cellulose and corn starch
Original language description
This paper deals with a study of the novel coprocessed dry binder Combilac(R), which contains 70% of alpha-lactose monohydrate, 20% of microcrystalline cellulose and 10% of native corn starch. These tests include flow properties, compressibility, lubricant sensitivity, tensile strength and disintegration time of tablets. Compressibility is evaluated by means of the energy profile of compression process, test of stress relaxation and tablet strength. The above-mentioned parameters are also evaluated in the physical mixture of alpha-lactose monohydrate, microcrystalline cellulose and native corn starch and compared with Combilac. Combilac shows much better flowability than the physical mixture of the used dry binders. Its compressibility is better, tablets possess a higher tensile strength. Neither Combilac, nor the physical mixture can be compressed without lubricants due to high friction and sticking to the matrix. Combilac has a higher lubricant sensitivity than the physical mixture of the dry binders. Disintegration time of Combilac tablets is comparable with the disintegration time of tablets made from the physical mixture.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmaceutical Development and Technology
ISSN
1083-7450
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
964-971
UT code for WoS article
000413910500004
EID of the result in the Scopus database
2-s2.0-84954201820