Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F18%3A39913352" target="_blank" >RIV/00216275:25310/18:39913352 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/18:10382194

Result on the web

<a href="http://dx.doi.org/10.2478/acph-2018-0030" target="_blank" >http://dx.doi.org/10.2478/acph-2018-0030</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/acph-2018-0030" target="_blank" >10.2478/acph-2018-0030</a>

Result language

angličtina

Original language name

Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release

Original language description

This paper evaluates and compares the properties of directly compressible tabletting materials and matrix tablets containing a combination of a-lactose monohydrate and microcrystalline cellulose in the 3: 1 ratio in a physical mixture and in a coprocessed dry binder. Tested parameters include flow properties, compressibility, compactibility and the rate of drug release from tablets. Compressibility is evaluated by means of the energy profile of the compression process. Compactibility is evaluated by means of the tensile strength of the tablets. Dissolution testing is done using the rotating basket method. Dissolution profiles are evaluated by non-linear regression analysis. Total energy of compression and plasticity values were higher in tabletting materials with the coprocessed dry binder. Increasing additions of polyvinyl alcohol decreased the values of total energy of compression, plasticity, tensile strength of tablets and drug release rate. Dissolution behaviour of tablets, which contained the physical mixture or coprocessed dry binder and the same amount of polyvinyl alcohol, was comparable.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Pharmaceutica

ISSN

1330-0075

e-ISSN

—

Volume of the periodical

68

Issue of the periodical within the volume

3

Country of publishing house

HR - CROATIA

Number of pages

17

Pages from-to

295-311

UT code for WoS article

000438066100003

EID of the result in the Scopus database

2-s2.0-85049806963