A study of tablets with a co-processed dry binder containing hypromellose and alpha-lactose monohydrate
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F14%3A39898172" target="_blank" >RIV/00216275:25310/14:39898172 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/14:10281668
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
A study of tablets with a co-processed dry binder containing hypromellose and alpha-lactose monohydrate
Original language description
The paper examines the co-processed dry binder RetaLac from the aspect of its compressibility and dissolution of the active ingredient from tablets. RetaLac contains a-lactose monohydrate and hypromellose in the identical proportion. The same parametersare tested in the corresponding physical mixtures of Flowlac100 and various types of hypromellose (Metolose 100SR, Metolose 4000SR, Metolose 100000SR) and compared with the substance RetaLac. Compressibility is evaluated by means of the energy profile ofcompression and tensile strength of tablets. The values of the total energy of compression and plasticity were higher in the substance RetaLac than in the physical mixtures of lactose and various types of hypromellose: tablet strength, on the contrary,was lower. Dissolution profile of the active ingredient from tablets with RetaLac corresponded to the dissolution profile of tablets from a physical mixture of Flowlac 100 and Metolose 4000SR.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Drug Delivery Science and Technology
ISSN
1773-2247
e-ISSN
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Volume of the periodical
24
Issue of the periodical within the volume
1
Country of publishing house
FR - FRANCE
Number of pages
5
Pages from-to
100-104
UT code for WoS article
000339928700014
EID of the result in the Scopus database
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