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A study of tablets with a co-processed dry binder containing hypromellose and alpha-lactose monohydrate

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F14%3A39898172" target="_blank" >RIV/00216275:25310/14:39898172 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11160/14:10281668

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    A study of tablets with a co-processed dry binder containing hypromellose and alpha-lactose monohydrate

  • Original language description

    The paper examines the co-processed dry binder RetaLac from the aspect of its compressibility and dissolution of the active ingredient from tablets. RetaLac contains a-lactose monohydrate and hypromellose in the identical proportion. The same parametersare tested in the corresponding physical mixtures of Flowlac100 and various types of hypromellose (Metolose 100SR, Metolose 4000SR, Metolose 100000SR) and compared with the substance RetaLac. Compressibility is evaluated by means of the energy profile ofcompression and tensile strength of tablets. The values of the total energy of compression and plasticity were higher in the substance RetaLac than in the physical mixtures of lactose and various types of hypromellose: tablet strength, on the contrary,was lower. Dissolution profile of the active ingredient from tablets with RetaLac corresponded to the dissolution profile of tablets from a physical mixture of Flowlac 100 and Metolose 4000SR.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Drug Delivery Science and Technology

  • ISSN

    1773-2247

  • e-ISSN

  • Volume of the periodical

    24

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    FR - FRANCE

  • Number of pages

    5

  • Pages from-to

    100-104

  • UT code for WoS article

    000339928700014

  • EID of the result in the Scopus database