Study of dual matrix tablets containing hypromellose of different viscosity degree and glyceryl dibehenate

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F16%3A39902251" target="_blank" >RIV/00216275:25310/16:39902251 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/16:10327946

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Study of dual matrix tablets containing hypromellose of different viscosity degree and glyceryl dibehenate

Original language description

Studies are described on the compressibility of directly compressible tableting materials containing two viscosity types of hypromellose in two concentrations and tableting materials containing additional glyceryl dibehenate, also in two concentrations. Compressibility is evaluated by means of the energy profile of the compression process and determination of tensile strength of tablets. Dissolution test examines the rate of release of the active ingredient from matrix tablets, which is subsequently evaluated mathematically. Increased concentrations of both hypromelloses and an addition of glyceryl dibehenate into tablets with both types of hypromellose improved compressibility. The rate of drug release was decreased with increasing viscosity degree of hypromellose and its increasing concentration. An addition of glyceryl dibehenate exerted the same influence on release as increased concentrations of the pertinent hypromellose.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Poloniae Pharmaceutica

ISSN

0001-6837

e-ISSN

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Volume of the periodical

73

Issue of the periodical within the volume

2

Country of publishing house

PL - POLAND

Number of pages

8

Pages from-to

461-468

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-84975142381