Release kinetics of tramadol hydrochloride from solid drug formulations
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F16%3A39902243" target="_blank" >RIV/00216275:25310/16:39902243 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Release kinetics of tramadol hydrochloride from solid drug formulations
Original language description
The aim of this paper is to present the use of a reaction and a dissolution kinetic approach for evaluating the dissolution profile of a drug. As model substances, two controlled-release formulations (with different type of matrix) with tramadol hydrochloride were chosen. Release kinetics of tramadol hydrochloride was studied at isothermal conditions (37 oC) and at different pH values for media used for dissolution. The dissolution profiles obtained by using HPLC with UV detection were fitted by the first-order kinetic model, Korsmeyer-Peppas, Higuchi, and Weibull models. The main results of regression analysis were the determination of the first-order release rate constant (k1), the release exponent (n) from Korsmeyer-Peppas model, Higuchi constant (KH), and the parameters of Weibull model.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Papers of the University of Pardubice, Series A, Faculty of Chemical Technology
ISSN
1211-5541
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
květen 2016
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
13
Pages from-to
67-79
UT code for WoS article
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EID of the result in the Scopus database
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