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In vitro release study of ketoprofen-loaded chitosan/polyaniline nanofibers

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00545306" target="_blank" >RIV/61389013:_____/21:00545306 - isvavai.cz</a>

  • Result on the web

    <a href="https://link.springer.com/article/10.1007%2Fs00289-020-03385-z" target="_blank" >https://link.springer.com/article/10.1007%2Fs00289-020-03385-z</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00289-020-03385-z" target="_blank" >10.1007/s00289-020-03385-z</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    In vitro release study of ketoprofen-loaded chitosan/polyaniline nanofibers

  • Original language description

    Chitosan/polyaniline nanofibers (CH/PANI) were prepared by an in situ oxidative polymerization of aniline in the presence of CH solution. An attractive development of nanofibers network provides free volume space for the easy encapsulation of drugs in the three-dimensional network structure. The CH/PANI hybrid was characterized by using Fourier transform infrared spectroscopy, scanning electron microscopy and X-ray diffractometry. Ketoprofen (KP), a model drug that contains a carboxylic group and a hydrophobic moiety, was loaded into CH/PANI hybrid. The release of KP from the hybrid was recorded in aqueous buffer solutions of pH 2, 6.7 and 7.4 simulating the case of oral administration. The release rate was found to be changing with the pH of the medium. The kinetics of the drug delivery system have been systematically studied by different models, which are commonly used, such as zero order, first order, Hixson–Crowell, Higuchi and Korsmeyer–Peppas models. The mechanism of release of the drug was found to follow the anomalous non-Fickian diffusion.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10404 - Polymer science

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Polymer Bulletin

  • ISSN

    0170-0839

  • e-ISSN

    1436-2449

  • Volume of the periodical

    78

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    14

  • Pages from-to

    5609-5622

  • UT code for WoS article

    000575725000004

  • EID of the result in the Scopus database

    2-s2.0-85092110692