In vitro release study of ketoprofen-loaded chitosan/polyaniline nanofibers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00545306" target="_blank" >RIV/61389013:_____/21:00545306 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs00289-020-03385-z" target="_blank" >https://link.springer.com/article/10.1007%2Fs00289-020-03385-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00289-020-03385-z" target="_blank" >10.1007/s00289-020-03385-z</a>
Alternative languages
Result language
angličtina
Original language name
In vitro release study of ketoprofen-loaded chitosan/polyaniline nanofibers
Original language description
Chitosan/polyaniline nanofibers (CH/PANI) were prepared by an in situ oxidative polymerization of aniline in the presence of CH solution. An attractive development of nanofibers network provides free volume space for the easy encapsulation of drugs in the three-dimensional network structure. The CH/PANI hybrid was characterized by using Fourier transform infrared spectroscopy, scanning electron microscopy and X-ray diffractometry. Ketoprofen (KP), a model drug that contains a carboxylic group and a hydrophobic moiety, was loaded into CH/PANI hybrid. The release of KP from the hybrid was recorded in aqueous buffer solutions of pH 2, 6.7 and 7.4 simulating the case of oral administration. The release rate was found to be changing with the pH of the medium. The kinetics of the drug delivery system have been systematically studied by different models, which are commonly used, such as zero order, first order, Hixson–Crowell, Higuchi and Korsmeyer–Peppas models. The mechanism of release of the drug was found to follow the anomalous non-Fickian diffusion.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10404 - Polymer science
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Polymer Bulletin
ISSN
0170-0839
e-ISSN
1436-2449
Volume of the periodical
78
Issue of the periodical within the volume
10
Country of publishing house
DE - GERMANY
Number of pages
14
Pages from-to
5609-5622
UT code for WoS article
000575725000004
EID of the result in the Scopus database
2-s2.0-85092110692