Fractal Aspects of Static and Dynamic Flow Properties of Pharmaceutical Excipients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F18%3A10382169" target="_blank" >RIV/00216208:11160/18:10382169 - isvavai.cz</a>

Result on the web

<a href="http://link.springer.com/article/10.1007/s12247-017-9302-0" target="_blank" >http://link.springer.com/article/10.1007/s12247-017-9302-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12247-017-9302-0" target="_blank" >10.1007/s12247-017-9302-0</a>

Result language

angličtina

Original language name

Fractal Aspects of Static and Dynamic Flow Properties of Pharmaceutical Excipients

Original language description

Characterisation of powder flow is important for pharmaceutical processing and manufacturing. This work aims at a better understanding of how fractal particle and bulk properties affect the static and dynamic flow of excipients. Traditional methods of flowability testing, e.g. the angle of repose or the flow through an orifice, were complemented by avalanching in a rotational drum. Dynamic image analysis provided a fractal contour line dimension of the powder bulk in the drum (bD(F)). This was compared to the contour line fractal dimension of particles (pD(F)) as obtained from the box-counting method. Avalanche testing was able to measure also cohesive materials that were otherwise difficult or not measurable at all using the classical methods. The values of the avalanche energy were in good agreement with the different flow properties of the samples. These flow properties showed good correlations with bD(F) in that poor flow properties were associated with a more rugged contour line of the bulk and hence higher bD(F). Interestingly, there was no correlation observed between pD(F) and bD(F), which may suggest that a distinct bulk structure typically emerges from the particles under dynamic flow. Future research should further clarify how fractal powder aspects affect pharmaceutical manufacturing processes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Pharmaceutical Innovation

ISSN

1872-5120

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

15-26

UT code for WoS article

000425309900002

EID of the result in the Scopus database

2-s2.0-85034756369