Introduction of the energy to break an avalanche as a promising parameter for powder flowability prediction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F20%3A10417798" target="_blank" >RIV/00216208:11160/20:10417798 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7GES6L0Jkh" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7GES6L0Jkh</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.powtec.2020.07.095" target="_blank" >10.1016/j.powtec.2020.07.095</a>

Result language

angličtina

Original language name

Introduction of the energy to break an avalanche as a promising parameter for powder flowability prediction

Original language description

Dynamic avalanche testing is a newer method useful even with cohesive powder samples. To evaluate flow properties of pharmaceutical powder excipients, break energy (BE) is introduced as a new promising avalanche parameter. Conventional pharmacopoeial methods and an annular shear cell were utilized to characterize 23 pharmaceutical powder samples including binary mixtures. Subsequently, rotating drum avalanching was studied to better understand behaviour of powders. A good linear regression between the energy to break a powder avalanche and powder cohesion with R^2 = 0.823 was detected. The relationship between BE and the flow function value, estimated by shear testing, allowed to identify two samples with excellent flow functions: Cellets 100 and Neusilin US2. The latter sample also had very low BE although the mass flow rate was the poorest observed out of 23 samples. Therefore, the BE from avalanching testing seems to be a sensitive measure of cohesion and flow function behaviour.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Powder Technology

ISSN

0032-5910

e-ISSN

—

Volume of the periodical

375

Issue of the periodical within the volume

September

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

33-41

UT code for WoS article

000573028500005

EID of the result in the Scopus database

2-s2.0-85088877110