Powder cohesion and energy to break an avalanche: Can we address surface heterogeneity?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F22%3A43925899" target="_blank" >RIV/60461373:22310/22:43925899 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/22:10451086
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0378517322007529?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0378517322007529?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpharm.2022.122198" target="_blank" >10.1016/j.ijpharm.2022.122198</a>
Alternative languages
Result language
angličtina
Original language name
Powder cohesion and energy to break an avalanche: Can we address surface heterogeneity?
Original language description
The aim of this work is to contribute to the theoretical investigation of cohesive powder surface properties regarding the surface energy both in a qualitative and quantitative way. The relationship between cohesion (shear testing), the energy to break avalanche (avalanche testing) and the surface energy heterogeneity (inverse gas chromatography, IGC) was investigated using binary mixtures of the cohesive drug meloxicam (M) in a range of 5–50% (w/w) and excipients, i.e., alginic acid (AA) and calcium alginate (AC), prepared by mixing and co-milling. A linear relationship was detected between the cohesion and energy to break an avalanche (R2 = 0.633) and the cohesion and specific surface area of the powders (R2 = 0.862). The surface energy heterogeneity measurement at a nominal surface coverage 0.04–0.10 allowed to compare the experimentally estimated work of cohesion (showing the cohesive interaction between the particles) with the theoretical estimation of work of adhesion between a drug and the host carrier. The preference of adhesive forces with the carrier materials was demonstrated in case of M. Better adhesion properties of AA were observed together with the highest dispersive energy, while interestingly, the lowest value of cohesion was also noted for this excipient.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Pharmaceutics
ISSN
0378-5173
e-ISSN
1873-3476
Volume of the periodical
626
Issue of the periodical within the volume
122198
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
nestrankovano
UT code for WoS article
000869411700009
EID of the result in the Scopus database
2-s2.0-85138837057