Adhesion force measurement by centrifuge technique as tool for predicting interactive mixture stability

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F21%3A43920577" target="_blank" >RIV/60461373:22310/21:43920577 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0263876220305189?dgcid=rss_sd_all" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0263876220305189?dgcid=rss_sd_all</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cherd.2020.10.012" target="_blank" >10.1016/j.cherd.2020.10.012</a>

Result language
angličtina
Original language name
Adhesion force measurement by centrifuge technique as tool for predicting interactive mixture stability
Original language description
An interactive mixture, i.e. a blend of larger carrier particles with drug particles adhered on their surfaces, is often used in pharmaceutical formulations for promoting powder flow, improving blend uniformity, reducing the segregation risk during manipulation, and improving the solubility of poorly water-soluble drug. Obtaining uniform and stable interactive mixtures require adhesion forces between fine drug and coarse carrier particles to exceed the cohesion forces between drug particles. This work was aimed at developing the methodology measuring the particle adhesion by centrifugation combined with the optical microscopy to predict interactions between components in the mixtures. In the pilot phase, excipient particles were chosen as model substances, both for the preparation of the carrier surface and deposited particles. As expected, our developed methodology was able to map the behaviour of particles on the rugged surfaces and provide the adhesion strength distribution used for comparing different material adhesion. It can also provide a measure of interactive unit stability when the mixture undergoes process treatment characterised by certain mechanical stress. © 2020 Institution of Chemical Engineers
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Project
<a href="/en/project/LO1613" target="_blank" >LO1613: Future materials</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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