PREDICTING INTERACTIVE MIXTURE STABILITY USING PARTICLE ADHESION MEASUREMENT BY CENTRIFUGING/IMAGE ANALYSIS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F19%3A43919621" target="_blank" >RIV/60461373:22310/19:43919621 - isvavai.cz</a>
Result on the web
<a href="https://www.icct.cz/AngiologyKlon-ICCT/media/system/2019/ICCT-2019-Proceedings.pdf" target="_blank" >https://www.icct.cz/AngiologyKlon-ICCT/media/system/2019/ICCT-2019-Proceedings.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
PREDICTING INTERACTIVE MIXTURE STABILITY USING PARTICLE ADHESION MEASUREMENT BY CENTRIFUGING/IMAGE ANALYSIS
Original language description
An interactive mixture, i.e. a blend of larger carrier particles with active pharmaceutical ingredient (API) particles adhered on their surfaces, is often used in pharmaceutical formulations for promoting powder flow, improving blend uniformity, reducing the segregation risk during manipulation, and improving the solubility of poorly water-soluble APIs. Obtaining uniform and stable interactive mixtures require adhesion forces between fine API and coarse carrier particles to exceed the cohesion forces between API particles.This work was aimed at developing the methodology measuring the particle adhesion by centrifugation combined with the optical microscopy to predict interactions between components in mixtures. Comparing our results to the results of interactive force measurement based on surface energy for the same analysed systems of excipients (Kollidon® VA64, Kollidon® 12, Soluplus®) and tadalafil, using centrifuge technique may overcome all the limitations of employing the atomic force microscopy (AFM) and inverse gas chromatography (IGC) for adhesion measurement.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Proceedings of the 7th International Conference on Chemical Technology
ISBN
978-80-88307-00-6
ISSN
2336-811X
e-ISSN
2336-8128
Number of pages
6
Pages from-to
275-280
Publisher name
Czech Society of Industrial Chemistry
Place of publication
Prague
Event location
Mikulov
Event date
Apr 15, 2019
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000515696600050