Measurement of the particulate interactions in binary mixtures using energy balance of the surface energy obtained by IGC

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F18%3A43916751" target="_blank" >RIV/60461373:22310/18:43916751 - isvavai.cz</a>
Result on the web
<a href="https://www.icct.cz/AngiologyKlon-ICCT/media/system/2018/ICCT-2018-Proceedings.pdf" target="_blank" >https://www.icct.cz/AngiologyKlon-ICCT/media/system/2018/ICCT-2018-Proceedings.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Measurement of the particulate interactions in binary mixtures using energy balance of the surface energy obtained by IGC
Original language description
The study was focused on the measurement of interactions between the components in the binary mixtures in terms of energy balance based on surface free energy and its dispersive and/or specific components. The binary mixtures were prepared in the various ratios of poorly water-soluble Tadalafil and carriers, i.e. Kollidon® 12 PF, Kollidon® VA 64, Parteck® MXP, or Soluplus® which are widely used in the solid dispersions, and Parteck® M DPI which can be used in dry powder inhalers. Inverse gas chromatography (IGC) was used to assess the surface parameters. The results indicate that energy analysis of binary mixtures obtained by IGC allows to predict the preferred interactions between the components (i.e. drug-excipient interactions) or whether the surface energy is utilized in another way (e.g. to form the particle agglomerates of one component) and therefore, the components do not interact. The works of adhesion and cohesion were also determined.
Czech name
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Czech description
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Project
<a href="/en/project/LO1613" target="_blank" >LO1613: Future materials</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
PROCEEDINGS of the 6th International Conference on Chemical Technology
ISBN
978-80-86238-77-7
ISSN
2336-8128
e-ISSN
2336-8128
Number of pages
5
Pages from-to
375-379
Publisher name
Česká společnost průmyslové chemie (ČSPCH)
Place of publication
Praha
Event location
Mikulov
Event date
Apr 16, 2018
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000461293800069

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