Effect of polymer type on the surface energy of acetaminophen solid dispersions prepared by melt method

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F17%3A43913262" target="_blank" >RIV/60461373:22310/17:43913262 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.ijpharm.2017.07.029" target="_blank" >http://dx.doi.org/10.1016/j.ijpharm.2017.07.029</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijpharm.2017.07.029" target="_blank" >10.1016/j.ijpharm.2017.07.029</a>

Result language

angličtina

Original language name

Effect of polymer type on the surface energy of acetaminophen solid dispersions prepared by melt method

Original language description

Many newly developed active pharmaceutical ingredients (APIs) have very low solubility in aqueous media. The preparation of solid dispersions (SDs) is one way of avoiding this problem. However, compound wettability and thus solubility are influenced by surface energy. In this study, we used inverse gas chromatography (IGC) to evaluate the surface energies of prepared SDs, and compared them with those obtained for physical mixtures (PMs). SDs containing different weight ratios of crystalline acetaminophen and one of three polymers (Kollidon? 12 PF, Kollidon? VA 64 or Soluplus?) were prepared by the melt-quenching of corresponding PMs. In all cases, as the polymer content increased, the surface energy decreased significantly. For the SDs and PMs containing Soluplus?, this decrease in surface energy showed the same non-linear trend. In the cases of Kollidon? 12 PF and Kollidon? VA 64, the trend was linear, with the SDs showing a steeper decrease in surface energy than the corresponding PMs. Typically, such decreases are ascribed to the dissolution of the crystalline structure of an API. Our results suggest that in the case of the Kollidons, the steeper decrease is caused by another mechanism, namely, strong API-Kollidon interaction leading to the less wettable surface of SDs.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

<a href="/en/project/LO1613" target="_blank" >LO1613: Future materials</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Pharmaceutics

ISSN

0378-5173

e-ISSN

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Volume of the periodical

530

Issue of the periodical within the volume

1-2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

107-112

UT code for WoS article

000410643800012

EID of the result in the Scopus database

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