Preparation of solid dispersion with respect to the dissolution rate of active substance

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F19%3A43919584" target="_blank" >RIV/60461373:22310/19:43919584 - isvavai.cz</a>

Result on the web

<a href="https://www.sheffield.ac.uk/agglom/2019/index#" target="_blank" >https://www.sheffield.ac.uk/agglom/2019/index#</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Preparation of solid dispersion with respect to the dissolution rate of active substance

Original language description

Solid dispersions (SDs) are one of widely and successfully applied methods to improve the solubility, dissolution rates and the bioavailability of poorly water-soluble drugs. SDs are commonly binary API-polymer systems, where API is molecularly dispersed in a polymeric matrix. Thus, the objective of this study was to prepare SDs by solvent evaporation and spray drying method and compare them with the physical mixtures (PMs) in terms of dissolution properties. Tadalafil was used as a model poorly water-soluble drug, which was mixed with three different hydrophilic polymer matrices, Kollidon® VA 64, Kollidon® 12 PF and Soluplus®. It was confirmed that hydrophilic polymers have a significant influence on the drug release from binary mixtures (SDs or PMs). The type of hydrophilic polymer can control if the drug release is either immediate or prolonged. Our results show that as the molecular weight of polymer increased, hydrophilic polymer more swollen and on the contrary, the drug release decreased. In this case of SDs, it means, that the presence of both Kollidons has a positive effect on the acceleration of tadalafil release, on the other hand, the presence of Soluplus® retarded its release. These results indicate possibility of different applications of SDs in pharmaceutical formulation, based on careful selection of the polymer co-former.

Czech name

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Czech description

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Type

A - Audiovisual production

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

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Place of publication

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