Characterization of Solid Dispersions Prepared by Melting Method

Result code in IS VaVaI
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Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Characterization of Solid Dispersions Prepared by Melting Method
Original language description
Nowadays, the pharmaceutical industry faces a challenge to formulate a large number of APIs that are almost insoluble in aqueous media. The preparation of solid dispersions (SD) is one of the promising methods for improving drug solubility and bioavailability. SDs are mostly binary API-polymer systems, where API is molecularly dispersed in a polymeric matrix. Thus, the aim of this work was to prepare SDs by melting method and compare them with corresponding physical mixtures (PM). Paracetamol was used as a model drug, which was mixed with three different hydrophilic polymer matrices (Kollidon® VA 64, Kollidon® 12 PF and Soluplus®) in various ratios. It was shown that the polymer type has an influence on the surface energy values and the dissolution rates of drugs. Moreover, it was found that the higher concentration of paracetamol in solid dispersions, and also the lower hardness of tablets cause faster dissolution.
Czech name
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Czech description
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Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of the 7th International Conference on Chemical Technology
ISBN
978-80-88307-00-6
ISSN
2336-811X
e-ISSN
2336-8128
Number of pages
6
Pages from-to
281-286
Publisher name
Czech Society of Industrial Chemistry
Place of publication
Prague
Event location
Mikulov
Event date
Apr 15, 2019
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000515696600051

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