A STUDY OF DISSOLUTION AND STABILITY KINETICS OF SOLID DOSAGE FORM PREPARED BY HOT-MELT EXTRUSION
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F15%3A43900717" target="_blank" >RIV/60461373:22310/15:43900717 - isvavai.cz</a>
Result on the web
<a href="http://www.icct.cz/2015/Full_Papers_ICCT_2015.pdf" target="_blank" >http://www.icct.cz/2015/Full_Papers_ICCT_2015.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
A STUDY OF DISSOLUTION AND STABILITY KINETICS OF SOLID DOSAGE FORM PREPARED BY HOT-MELT EXTRUSION
Original language description
The work is focused on the preparation of solid dispersion in order to prepare solid solution. Solid dispersions were prepared using hot-melt extrusion. Characterization of solid dispersions was performed by X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC). The stability of solid dispersions was also studied and was characterized by XRPD. The dissolution rate was studied by the flow-through cell apparatus (USP 4). It was prepared 5 mixtures of different composition API/ polymer. As a model drug Paracetamol and Phenylephrine hydrochloride or both of them in the mixture were chosen. Kollidon(R) VA64 was used as polymer. The only composition resulting to solid solution by hot-melt extrusion technique was that with higher contentof polymer (66,7 % polymer, 33,3 % API/ both APIs). From the dissolution experiments it was found that the initial dissolution rate is greatly affected by wetting the sample and the distribution of particle size in the sample. The modifi
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
JJ - Other materials
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Proceedings of the 3rd International Conference on Chemical Technology
ISBN
978-80-86238-79-1
ISSN
2336-811X
e-ISSN
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Number of pages
5
Pages from-to
484-488
Publisher name
Česká společnost průmyslové chemie (ČSPCH)
Place of publication
Praha
Event location
Mikulov
Event date
Apr 13, 2015
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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