Methods for the preparation of amorphous solid dispersions - A comparative study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F17%3A10371919" target="_blank" >RIV/00216208:11160/17:10371919 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1773224716304105" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1773224716304105</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jddst.2017.02.005" target="_blank" >10.1016/j.jddst.2017.02.005</a>
Alternative languages
Result language
angličtina
Original language name
Methods for the preparation of amorphous solid dispersions - A comparative study
Original language description
Solid dispersion is considered one of the most successful strategies for improving the dissolution and absorption of poorly water-soluble APIs. The primary focus of this study was to investigate the effects of methods of solid dispersion preparation on the pharmaceutically important physicochemical properties of a product based on Soluplus(R) as the polymer carrier and febuxostat as the model BCS II API. The methods of preparation evaluated were based on melt and solvent mechanisms. The samples prepared were evaluated by modulated differential scanning calorimetry, solid state NMR, Raman spectroscopy, XRPD, scanning electron microscopy, and BET analysis. Differences among the solid dispersions obtained by the specific methods and their mechanisms were clearly observed in in-vitro testing. The dissolution behaviour was shown to be influenced not only by particle characteristics such as the size and specific surface area, but also by the interactions between the API and the polymer matrix on the molecular level (e.g. non-covalent interactions). The set of measurements showed that similar Methods of preparation do not lead to solid dispersion systems of similar characteristics. Surprisingly, similar dissolution profiles were found in samples prepared by very different methods although their physical-chemical characteristics differed significantly, and vice versa.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Drug Delivery Science and Technology
ISSN
1773-2247
e-ISSN
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Volume of the periodical
38
Issue of the periodical within the volume
April
Country of publishing house
FR - FRANCE
Number of pages
10
Pages from-to
125-134
UT code for WoS article
000397686700015
EID of the result in the Scopus database
2-s2.0-85013634148