Drug - polymer properties in solid dispersion and physical mixture and their effect to dissolution rate

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43897697" target="_blank" >RIV/60461373:22310/14:43897697 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22340/14:43897697
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Drug - polymer properties in solid dispersion and physical mixture and their effect to dissolution rate
Original language description
The objective of this study was to investigate the effect of different type of formulation (solid dispersion and physical mixture) with a poorly soluble active pharmaceutical ingredient (API) on water vapour sorption equilibria and the influence of the API-polymer interactions on the dissolution rate of the API. X-ray diffraction, Scanning Electron Microscopy, moisture sorption analysis, infrared (IR) spectroscopy and ATR-FTIR Imaging during dissolution were performed on API-polymer system (Aprepitant-PVP). The amorphous solid dispersion was prepared by spray drying. The interactions between the API and polymer molecules caused the water sorption isotherms of solid dispersions to deviate from those of ideal mixtures. The moisture sorption isotherm waslower in comparison with the isotherms of physical mixtures. The nature of the API-polymer interaction was explained by shifts in the characteristic bands of the IR spectra of the solid dispersions compared to the pure components. The dis
Czech name
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Czech description
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Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of the 41st International Conference of Slovak Society of Chemical Engineering
ISBN
978-80-89475-13-1
ISSN
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e-ISSN
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Number of pages
10
Pages from-to
397-406
Publisher name
Slovak Society of Chemical Engineering
Place of publication
Bratislava
Event location
Tatranské Matliare
Event date
May 26, 2014
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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