EFFECT OF HYDROPHILIC POLYMERS ON DISSOLUTION PROFILES OF BINARY MIXTURES
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F17%3A43915241" target="_blank" >RIV/60461373:22310/17:43915241 - isvavai.cz</a>
Result on the web
<a href="http://www.icct.cz/AngiologyKlon-ICCT/media/system/ICCT2017-full_papers.pdf" target="_blank" >http://www.icct.cz/AngiologyKlon-ICCT/media/system/ICCT2017-full_papers.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
EFFECT OF HYDROPHILIC POLYMERS ON DISSOLUTION PROFILES OF BINARY MIXTURES
Original language description
Solubility and dissolution rate are limiting step in absorption of an active pharmaceutical ingredient (API), especially for a poorly water-soluble drug substance. This study is aimed at determining the effect of hydrophilic polymers (Kollidon? 12 PF, Kollidon? VA 64 or Soluplus?) on dissolution profiles of acetaminophen binary mixtures: physical mixtures of API and polymer and corresponding solid dispersions which were prepared by melt method. An erosion-diffusion mechanism of acetaminophen release was also evaluated. The Wood apparatus was used to determine the intrinsic dissolution rate of acetaminophen and its dissolution profiles of release were measured using a flow-through cell apparatus in an open-loop configuration (USP4). It was found that all of hydrophilic polymers formed gel layer. Kollidon? VA 64 and Soluplus? retarded the acetaminophen release and thus, the diffusion mechanism dominated. On the other hand, Kollidon? 12 PF accelerated the acetaminophen release and in this case, the erosion mechanism dominated.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Proceedings of the 5th International Conference on Chemical Technology
ISBN
978-80-86238-65-4
ISSN
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e-ISSN
neuvedeno
Number of pages
5
Pages from-to
445-449
Publisher name
Česká společnost průmyslové chemie (ČSPCH)
Place of publication
Praha
Event location
Mikulov
Event date
Apr 10, 2017
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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