Green profiling of aprotic versus protic ionic liquids: Synthesis and microbial toxicity of analogous structures
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F18%3A10388433" target="_blank" >RIV/00216208:11160/18:10388433 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S2352554117300487" target="_blank" >http://www.sciencedirect.com/science/article/pii/S2352554117300487</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.scp.2017.11.001" target="_blank" >10.1016/j.scp.2017.11.001</a>
Alternative languages
Result language
angličtina
Original language name
Green profiling of aprotic versus protic ionic liquids: Synthesis and microbial toxicity of analogous structures
Original language description
How does the variation in the ionic nature of ionic liquids (ILs) affect their antimicrobial properties? To answer this question with a direct connection to the molecular structure of ILs is integral for the design of new task specific ILs. The effect of ionic nature can be investigated through a comparison between analogous aprotic and protic ILs. However, while there have been extensive studies on the toxicology of both aprotic and protic ILs, the number of different structures and procedures employed makes quantitative comparison impossible. To address this, a series of analogous N,N,N-trimethylethanolammonium (cholinium) derived aprotic ILs (AILs) and N,N-dimethylethanolammonium derived protic ILs (PILs) with acetate, hexanoate, D,L-mandelate and 3-ethoxypropionate anions were prepared and characterised. All ILs were subsequently screened for antimicrobial activity against eight bacterial and twelve fungi strains. From the antimicrobial activity screening, little difference was found between the toxicities of AILs and PILs with shorter chains terminating in hydroxyl functional groups (e.g cholinium hexanoate and N,N-dimethylethanolammonium hexanoate). Variations between anion structure demonstrated slightly higher toxicities for more lipophilic anions. Antimicrobial activities were found to significantly increase for ILs with a long ether chain functional groups in the cation, due to the enhanced surfactant properties of these long chain cations. The importance of toxicity screening of analogous series of AILs and PILs as part of a future comprehensive biodegradation analysis has also been proposed based on postulated IL breakdown pathways.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Sustainable Chemistry and Pharmacy
ISSN
2352-5541
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
March
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
17-26
UT code for WoS article
000426418900003
EID of the result in the Scopus database
2-s2.0-85036662972