Influence of cationic, anionic or non-charged substituents on photodynamic activity of water-soluble zinc (aza)phthalocyanines

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F19%3A10409915" target="_blank" >RIV/00216208:11160/19:10409915 - isvavai.cz</a>
Result on the web
<a href="http://www.spiedigitallibrary.org/conference-proceedings-of-spie/11070/110709M/Influence-of-cationic-anionic-or-non-charged-substituents-on-photodynamic/10.1117/12.2525591.full" target="_blank" >http://www.spiedigitallibrary.org/conference-proceedings-of-spie/11070/110709M/Influence-of-cationic-anionic-or-non-charged-substituents-on-photodynamic/10.1117/12.2525591.full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1117/12.2525591" target="_blank" >10.1117/12.2525591</a>

Result language
angličtina
Original language name
Influence of cationic, anionic or non-charged substituents on photodynamic activity of water-soluble zinc (aza)phthalocyanines
Original language description
Solubility of (aza)phthalocyanines ((Aza)Pc) in water is very limited due to their flat aromatic core that makes them prone to aggregation. Stacking of (Aza)Pc cores (forming dimers or higher-order aggregates) leads to quenching of their excited states - fluorescence and 1O2 production [1]. Several approaches to improve the solubility have been described, but truly non aggregating water-soluble (Aza)Pcs are still scarce [2-7]. Here we present a series of novel water-soluble hydrophilic and amphiphilic zinc (Aza)Pcs with differently charged (cationic and anionic) as well as non-charged peripheral substituents. These compounds were directly compared to several clinically approved photosensitizers (PSs; verteporfin, temoporfin, Photosens, methylene blue and protoporphyrin IX - a photodynamically active product of a prodrug 5-aminolevulinic acid).
Czech name
—
Czech description
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Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
17th International Photodynamic Association World Congress
ISBN
978-1-5106-2833-5
ISSN
0277-786X
e-ISSN
1996-756X
Number of pages
4
Pages from-to
4
Publisher name
Society of Photo-Optical Instrumentation Engineers
Place of publication
Bellingham
Event location
Cambridge
Event date
Jun 28, 2019
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000511105600065

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