A Mixture of Phenolic Metabolites of Quercetin Can Decrease Elevated Blood Pressure of Spontaneously Hypertensive Rats Even in Low Doses
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F20%3A10416951" target="_blank" >RIV/00216208:11160/20:10416951 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=LApu30ceMk" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=LApu30ceMk</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/nu12010213" target="_blank" >10.3390/nu12010213</a>
Alternative languages
Result language
angličtina
Original language name
A Mixture of Phenolic Metabolites of Quercetin Can Decrease Elevated Blood Pressure of Spontaneously Hypertensive Rats Even in Low Doses
Original language description
Quercetin has been shown to decrease arterial blood pressure when given orally. Its has however low bioavailability. Hence its metabolites could rather be responsible for this effect. In this study, we have tested three combinations of colonic metabolites of quercetin, 3,4-dihydroxyphenylacetic acid (DHPA), 4-methylcatechol (4MC), and 3-(3-hydroxyphenyl)propionic acid (3HPPA). The effect of DHPA and 4MC was mild and very short-termed. A combination of DHPA with 3HPPA caused more pronounced effects, which were also rather short-lived. The last combination of 3HPPA and 4MC caused a long-lasting effect. We suppose that certain combinations of quercetin metabolites have a more profound antihypertensive effect than single metabolites.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nutrients
ISSN
2072-6643
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
1
Country of publishing house
CH - SWITZERLAND
Number of pages
6
Pages from-to
213
UT code for WoS article
000516825500213
EID of the result in the Scopus database
2-s2.0-85078034950