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In vitro assessment of polyethylene glycol and polyvinylpyrrolidone as hydrophilic additives on bioseparation by polysulfone membranes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F20%3A10417469" target="_blank" >RIV/00216208:11160/20:10417469 - isvavai.cz</a>

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=GnatlaOWBV" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=GnatlaOWBV</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s10853-019-04123-1" target="_blank" >10.1007/s10853-019-04123-1</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    In vitro assessment of polyethylene glycol and polyvinylpyrrolidone as hydrophilic additives on bioseparation by polysulfone membranes

  • Original language description

    Considering the continuous increment of morbidity in patients with renal disease, the improvement of polymeric membranes characteristics for haemodialysis is a challenging issue. The efficient removal of middle size uremic toxins, as well as biocompatibility is crucial characteristics to ameliorate chronic kidney disease patients&apos; outcomes. In this study, polysulfone membranes with different hydrophilic additives, molecular weight and concentrations were prepared by spin coating method, followed by phase inversion via immersion precipitation. The removal of urea, lysozyme and bovine serum albumin was studied using a miniaturized flow system, mimicking haemodialysis conditions. The optimal composition was 15.0 wt% of polysulfone and 2.5 wt% of polyvinylpyrrolidone K30. This selected membrane was fully permeable for urea, showed up to 50% rejection of lysozyme and very high rejection of albumin. The additive PVP K30 played important role in the improvement of porosity, without compromising the mechanical strength of the membrane. The biocompatibility of membrane was evaluated by material-induced haemolysis and platelet activation tests. The platelet activation and haemolysis were negligible, compared to other biocompatible materials. These results confirmed the haemocompatibility of the optimized membrane. Therefore, the membrane is not expected to modulate the biological response, when used for the haemodialysis treatment.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

    <a href="/en/project/EF16_019%2F0000841" target="_blank" >EF16_019/0000841: Efficiency and safety improvement of current drugs and nutraceuticals: advanced methods - new challenges</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Materials Science

  • ISSN

    0022-2461

  • e-ISSN

  • Volume of the periodical

    55

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    16

  • Pages from-to

    1292-1307

  • UT code for WoS article

    000490838300002

  • EID of the result in the Scopus database

    2-s2.0-85074198502