In vitro assessment of polyethylene glycol and polyvinylpyrrolidone as hydrophilic additives on bioseparation by polysulfone membranes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F20%3A10417469" target="_blank" >RIV/00216208:11160/20:10417469 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=GnatlaOWBV" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=GnatlaOWBV</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10853-019-04123-1" target="_blank" >10.1007/s10853-019-04123-1</a>
Alternative languages
Result language
angličtina
Original language name
In vitro assessment of polyethylene glycol and polyvinylpyrrolidone as hydrophilic additives on bioseparation by polysulfone membranes
Original language description
Considering the continuous increment of morbidity in patients with renal disease, the improvement of polymeric membranes characteristics for haemodialysis is a challenging issue. The efficient removal of middle size uremic toxins, as well as biocompatibility is crucial characteristics to ameliorate chronic kidney disease patients' outcomes. In this study, polysulfone membranes with different hydrophilic additives, molecular weight and concentrations were prepared by spin coating method, followed by phase inversion via immersion precipitation. The removal of urea, lysozyme and bovine serum albumin was studied using a miniaturized flow system, mimicking haemodialysis conditions. The optimal composition was 15.0 wt% of polysulfone and 2.5 wt% of polyvinylpyrrolidone K30. This selected membrane was fully permeable for urea, showed up to 50% rejection of lysozyme and very high rejection of albumin. The additive PVP K30 played important role in the improvement of porosity, without compromising the mechanical strength of the membrane. The biocompatibility of membrane was evaluated by material-induced haemolysis and platelet activation tests. The platelet activation and haemolysis were negligible, compared to other biocompatible materials. These results confirmed the haemocompatibility of the optimized membrane. Therefore, the membrane is not expected to modulate the biological response, when used for the haemodialysis treatment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/EF16_019%2F0000841" target="_blank" >EF16_019/0000841: Efficiency and safety improvement of current drugs and nutraceuticals: advanced methods - new challenges</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Materials Science
ISSN
0022-2461
e-ISSN
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Volume of the periodical
55
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
1292-1307
UT code for WoS article
000490838300002
EID of the result in the Scopus database
2-s2.0-85074198502