The effects of bisphenols on the cardiovascular system ex vivo and in vivo
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F23%3A10471056" target="_blank" >RIV/00216208:11160/23:10471056 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=96RUm1amcZ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=96RUm1amcZ</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.chemosphere.2022.137565" target="_blank" >10.1016/j.chemosphere.2022.137565</a>
Alternative languages
Result language
angličtina
Original language name
The effects of bisphenols on the cardiovascular system ex vivo and in vivo
Original language description
Humans are commonly and regularly exposed to bisphenols, but their cardiovascular effects were ambiguous or not know due to absence of studies. The aim of this study was to test 14 bisphenols (A, AF, AP, B, BP, C, E, F, G, M, P, PH, S and Z), and compare their effects in vitro (human and rat cell lines), ex vivo (isolated rat aorta) and in vivo (Wistar Han rats, acutely or chronically exposed to low environmental and high toxic doses). The majority of the tested bisphenols relaxed rat aorta, but their potency varied markedly. The mechanism of action was likely based on the inhibition of calcium influx via L-type calcium channels. The cytotoxicity of bisphenols towards cell lines showed variable potencies. The in vivo acute effects of three doses (0.005, 0.05 and 2.5 mg/kg) of bisphenol AF and 3 other analogues (A, S and F) on the cardiovascular system were, however, rather biologically negligible. The most potent bisphenol, AF, administered chronically had also no impact on arterial blood pressure.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemosphere
ISSN
0045-6535
e-ISSN
1879-1298
Volume of the periodical
313
Issue of the periodical within the volume
February
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
137565
UT code for WoS article
000904035100005
EID of the result in the Scopus database
2-s2.0-85144408457