Long-term exposure to very low doses of bisphenol S affects female reproduction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F18%3A76948" target="_blank" >RIV/60460709:41210/18:76948 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/18:10375514 RIV/00027014:_____/18:N0000111
Result on the web
<a href="http://dx.doi.org/10.1530/REP-18-0092" target="_blank" >http://dx.doi.org/10.1530/REP-18-0092</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1530/REP-18-0092" target="_blank" >10.1530/REP-18-0092</a>
Alternative languages
Result language
angličtina
Original language name
Long-term exposure to very low doses of bisphenol S affects female reproduction
Original language description
Bisphenols belong to the endocrine disruptors, affecting reproduction even in extremely low doses. Bisphenol S (BPS) has become widely used as a substitute for the earlier-used bisphenol A, however, its harmlessness is questionable. The aim of this study was to evaluate the effect of BPS on folliculogenesis and oocyte quality after in vivo exposure to low doses of BPS. Four-week-old ICR females were exposed to vehicle control, BPS1, BPS2, BPS3 and BPS4 for 4 weeks. Ovaries were subjected to stereology and nano liquid chromatography-mass spectrometry. Simultaneously, metaphase II oocytes were obtained after pregnant mare serum gonadotrophin and human chorionic gonadotrophin administration, followed by immunostaining. In particular, mating and two-cell embryo flushing were performed. We observed that BPS decreases the amount of ovarian follicles and BPS2 affects the volume of antral follicles. Accordingly, ovarian proteome is affected after BPS2 treatment. While BPS2 dosing results mainly in cytoskelet
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
REPRODUCTION
ISSN
1470-1626
e-ISSN
1741-7899
Volume of the periodical
156
Issue of the periodical within the volume
1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
11
Pages from-to
47-57
UT code for WoS article
000440011400013
EID of the result in the Scopus database
2-s2.0-85049623395