The bisphenol S contamination level observed in human follicular fluid affects the development of porcine oocytes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F23%3A10005786" target="_blank" >RIV/00027014:_____/23:10005786 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/23:00130788 RIV/00216208:11110/23:10459068 RIV/00216208:11120/23:43925376 RIV/00216208:11140/23:10459068 RIV/65269705:_____/23:00077907

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fcell.2023.1145182/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcell.2023.1145182/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fcell.2023.1145182" target="_blank" >10.3389/fcell.2023.1145182</a>

Result language

angličtina

Original language name

The bisphenol S contamination level observed in human follicular fluid affects the development of porcine oocytes

Original language description

Bisphenol S (BPS), the main replacement for bisphenol A (BPA), is thought to be toxic, but limited information is available on the effects of Bisphenol S on ovarian follicles. In our study, we demonstrated the presence of Bisphenol S in the follicular fluid of women at a concentration of 22.4 nM. The effect of such concentrations of Bisphenol S on oocyte maturation and subsequent embryo development is still unknown. Therefore, we focused on the effect of Bisphenol S on in vitro oocyte maturation, fertilization, and embryo development. As a model, we used porcine oocytes, which show many physiological similarities to human oocytes. Oocytes were exposed to Bisphenol S concentrations similar to those detected in female patients in the ART clinic. We found a decreased ability of oocytes to successfully complete meiotic maturation. Mature oocytes showed an increased frequency of meiotic spindle abnormalities and chromosome misalignment. Alarming associations of oocyte Bisphenol S exposure with the occurrence of aneuploidy and changes in the distribution of mitochondria and mitochondrial proteins were demonstrated for the first time. However, the number and quality of blastocysts derived from oocytes that successfully completed meiotic maturation under the influence of Bisphenol S was not affected.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10604 - Reproductive biology (medical aspects to be 3)

Project

<a href="/en/project/NV18-01-00544" target="_blank" >NV18-01-00544: Bisphenols as recent endocrine disruptors endangering human reproduction</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Cell and Developmental Biology

ISSN

2296-634X

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

April

Country of publishing house

CH - SWITZERLAND

Number of pages

12

Pages from-to

1145182

UT code for WoS article

000975622600001

EID of the result in the Scopus database

2-s2.0-85153485119