Chitosan- and levan-based wound dressings crosslinked with dialdehyde levan: Structural and biological stability under climatic aging

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F25%3A10505434" target="_blank" >RIV/00216208:11160/25:10505434 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3jrxCQskaN" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3jrxCQskaN</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijbiomac.2025.146207" target="_blank" >10.1016/j.ijbiomac.2025.146207</a>

Result language

angličtina

Original language name

Chitosan- and levan-based wound dressings crosslinked with dialdehyde levan: Structural and biological stability under climatic aging

Original language description

Wounds are a global health challenge that often causes serious consequences in terms of morbidity or mortality. However, good wound dressings should retain their properties for an adequate period to avoid risking the health and lives of patients. Therefore, in this study, we first compared the long-term stability and biological performance of two polysaccharide-based sponges-chitosan- and levan-based-crosslinked with dialdehyde levan synthesized by our team. The composites were stored in a climatic chamber for six months under constant temperature and humidity conditions. After each month, a series of analyses characterizing the physicochemical and biological properties of the composite were performed, evaluating their usefulness for their potential use as wound dressing materials. The results showed that the levan-based sponge maintained its structure for up to 4 months of storage in the climate chamber, while the chitosan-based sponge retained its structure throughout the study period. A slight decrease in physicochemical and biological properties was observed in both cases during this time. However, this decrease did not affect the proper functioning of the composites, suggesting that both materials remain viable for use in wound healing applications. Notably, chitosan-based sponges showed superior long-term stability, making them a more reliable material for extended wound dressing applications.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Biological Macromolecules

ISSN

0141-8130

e-ISSN

1879-0003

Volume of the periodical

321

Issue of the periodical within the volume

September

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

18

Pages from-to

146207

UT code for WoS article

001540522800006

EID of the result in the Scopus database

2-s2.0-105011167583