Seroepidemiological and molecular investigations of infections with Crimean Congo hemorrhagic fever virus in Kazakhstan.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11220%2F19%3A10381543" target="_blank" >RIV/00216208:11220/19:10381543 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hm1HkEblgb" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hm1HkEblgb</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijid.2018.10.015" target="_blank" >10.1016/j.ijid.2018.10.015</a>

Result language

angličtina

Original language name

Seroepidemiological and molecular investigations of infections with Crimean Congo hemorrhagic fever virus in Kazakhstan.

Original language description

Objectives The aim of this study was to detect the seroprevalence of Crimean-Congo haemorrhagic fever virus (CCHFV) in patients with fever of unknown origin (FUO) in endemic (Kyzylorda) and non-endemic (Almaty) oblasts of Kazakhstan. Methods Paired serum samples from 802 patients with FUO were collected. Serum samples were investigated by ELISA to detect IgG and IgM antibodies against CCHFV. Sera with suspected acute infection were further investigated by RT-PCR to detect the viral RNA. Results IgG antibodies were detected in 12.7% of the sera from both oblasts. Acute infection was shown by IgM ELISA in four patients from Kyzylorda, with only one developing severe CCHF. Viral RNA was found by RT-PCR in the other three patients&apos; sera. Phylogenetic analysis of partial L and S segments revealed CCHFV genotype Asia 2 and a possible reassortment between the genotypes Asia 1/Asia 2. Animal husbandry, such as working with cattle and horses, was significantly associated with CCHFV seropositivity. Conclusions The antibodies and viral RNA detected in sera indicate that mild or even asymptomatic CCHFV infections are presented in Kazakhstan. This study describes the circulation of CCHFV in the so far non-endemic Almaty oblast for the first time. In conclusion, physicians treating patients with FUO in Kazakhstan should be aware of mild CCHF.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30303 - Infectious Diseases

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Infectious Diseases

ISSN

1201-9712

e-ISSN

—

Volume of the periodical

78

Issue of the periodical within the volume

January

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

121-127

UT code for WoS article

000452810600020

EID of the result in the Scopus database

2-s2.0-85057574458