Functional interactions between the alpha(1b)-adrenoceptor and Galpha(11) are compromised by de-palmitoylation of the G protein but not of the receptor.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F05%3A00008056" target="_blank" >RIV/00216208:11310/05:00008056 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/06:00039259 RIV/00216208:11310/05:8056

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Functional interactions between the alpha(1b)-adrenoceptor and Galpha(11) are compromised by de-palmitoylation of the G protein but not of the receptor.

Original language description

Functional analysis of selected mutants of the alpha(1b)-AR and Galpha(11) protein co-expressed in HEK-293 cells revealed that palmitoylation of the receptor does not regulate cognate G protein activation but palmitoylation of Galpha(11) is important.

Czech name

Funkční interakce mezi alfa(1b)-adrenoceptorem a Galfa(11) jsou ohroženy depalmitoylací G proteinu, ale nikoliv receptoru.

Czech description

Analýza funkčních vlastností vybraných mutant alfa(1b)-AR a Galfa(11) proteinu exprimovaných v HEK-293 buňkách odhalila, že palmitoylace receptoru neovlivňuje aktivaci příslušného G proteinu, ale palmitoylace Galfa(11) je důležitá v přenosu signálu.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cellular Signalling

ISSN

0898-6568

e-ISSN

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Volume of the periodical

17

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

1-8

UT code for WoS article

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EID of the result in the Scopus database

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