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Lasioglossins: Three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae)

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F09%3A10000817" target="_blank" >RIV/00216208:11310/09:10000817 - isvavai.cz</a>

  • Alternative codes found

    RIV/61388963:_____/09:00329288

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Lasioglossins: Three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae)

  • Original language description

    Three novel antimicrobial peptides H-Val-Asn-Trp-Lys-Lys-Val-Leu-Gly-Lys-Ile-Ile-Lys-Val-Ala-Lys-NH2 (LL-I), H-Val-Asn-Trp-Lys-Lys-Ile-Leu-Gly-Lys-Ile-Ile-Lys-Val-Ala-Lys-NH2 (LL-II) and H-Val-Asn-Trp-Lys-Lys-Ile-Leu-Gly-Lys-Ile-Ile-Lys-Val-Val-Lys-NH2 (LL-III) designated lasioglossins were identified in the venom of the wild be Lasioglossum laticeps. They possess high antimicrobial activity against both Gram-positive and -negative bacteria and low hemolytic activity. As indicated by CD and NMR spectroscopy, lasioglossins can adopt an amphipathic ?-helical secondary structure in an anisotropic environment such as the bacterial cell membrane. NMR study confirmed that this ?-helical structure is curved with a concave hydrophobic and convex hydrophilic side.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CC - Organic chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA203%2F08%2F0536" target="_blank" >GA203/08/0536: Antimicrobial peptides from insects for possible therapeutic applications</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2009

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    CHEMBIOCHEM

  • ISSN

    1439-4227

  • e-ISSN

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    11

  • Pages from-to

  • UT code for WoS article

    000269279700024

  • EID of the result in the Scopus database