Novel antimicrobial peptides from the venom of the eusocial bee Halictus sexcinctus (Hymenoptera: Halictidae) and their analogs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F10%3A00351367" target="_blank" >RIV/61388963:_____/10:00351367 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/10:10080423

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Novel antimicrobial peptides from the venom of the eusocial bee Halictus sexcinctus (Hymenoptera: Halictidae) and their analogs

Original language description

Two novel antimicrobial peptides Gly-Met-Trp-Ser-Lys-Ile-Leu-Gly-His-Leu-Ile-Arg-NH2 (HAL-1) and Gly-Lys-Trp-Met-Ser-Leu-Leu-Lys-His-Ile-Leu-Lys-NH2 (HAL-2) designated halictines were identified in the venom of the wild bee Halictus sexcinctus. They possess high antimicrobial activity against both Gram-positive and -negative bacteria and noticeable hemolytic activity. As indicated by CD and NMR spectroscopy, halictines can adopt an amphipathic alpha-helical secondary structure in an anisotropic environment such as the bacterial cell membrane. Altogether we prepared 51 of HAL-1 and HAL-2 analogs to study the effect of such structural parameters as cationicity, hydrophobicity, alpha-helicity, amphipathicity, and truncation on antimicrobial and hemolyticactivities.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

<a href="/en/project/GA203%2F08%2F0536" target="_blank" >GA203/08/0536: Antimicrobial peptides from insects for possible therapeutic applications</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Amino Acids

ISSN

0939-4451

e-ISSN

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Volume of the periodical

39

Issue of the periodical within the volume

3

Country of publishing house

AT - AUSTRIA

Number of pages

13

Pages from-to

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UT code for WoS article

000280237600013

EID of the result in the Scopus database

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