Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F09%3A10001172" target="_blank" >RIV/00216208:11310/09:10001172 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/09:00333023

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III

Original language description

The study reports of several functional complexes of recombinant human GCPIII that allow for a direct comparison with equivalent GCPII complexes. That reveals differences in the organization of specificity pockets, in surface charge distribution, and inthe occupancy of the co-catalytic zinc sites. The data presented here provide information that should prove to be essential for the structurally- aided design of GCPIII-specific ligands.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/1M0508" target="_blank" >1M0508: New Antivirals and Antineoplastics</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

FEBS JOURNAL

ISSN

1742-464X

e-ISSN

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Volume of the periodical

276

Issue of the periodical within the volume

16

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

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UT code for WoS article

000268466600016

EID of the result in the Scopus database

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