Quantitative Structure-Electrochemistry Relationship of 1-Phenyl- 5-benzyl-sulfanyltetrazoles and Their Electrooxidation as a Metabolic Model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F10%3A10055298" target="_blank" >RIV/00216208:11310/10:10055298 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/10:00300532
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Quantitative Structure-Electrochemistry Relationship of 1-Phenyl- 5-benzyl-sulfanyltetrazoles and Their Electrooxidation as a Metabolic Model
Original language description
The quantitative structure-electrochemistry relationships study of nineteen derivatives of 1-phenyl-5-benzylsulfanyltetrazole, that seem to be very promising antimycobacterial drugs, resulted in a good correlation relationship between half-wave potentialand energy of HOMO orbital. The study of electrochemical oxidation of these compounds as a model of their possible metabolic degradation was performed. It was possible to propose a scheme of their electrochemical oxidation: the electrochemical oxidationstarts on the methoxy group, where by elimination of one electron the radical cation with very short life-time is formed. The free electron is translocated to the position 2, followed by closing of new cycle with -CH2- of benzylsulfanyl moiety. In the case of 2-methoxyphenyl tetrazoles this process is followed by the desintegration of the tetrazole ring.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Electroanalysis
ISSN
1040-0397
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
17-18
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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