The alfa-galactosidase type A gene aglA from Aspergillus niger encodes a fully functional alfa-N-acetylgalactosaminidase

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F10%3A10057598" target="_blank" >RIV/00216208:11310/10:10057598 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The alfa-galactosidase type A gene aglA from Aspergillus niger encodes a fully functional alfa-N-acetylgalactosaminidase

Original language description

Two genes in the genome of Aspergillus niger, aglA and aglB, have been assigned to encode for alfa-D-galactosidases variant A and B. However, analyses of primary and 3D structures based on structural models of these two enzymes revealed significant differences in their active centers suggesting important differences in their specificity for the hydrolyzed carbohydrates. To test this unexpected finding, a large screening of libraries from 42 strains of filamentous fungi succeeded in identifying an enzymefrom A. niger CCIM K2 that exhibited both alfa-galactosidase and alfa-N-acetylgalactosaminidase activities, with the latter activity predominating.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GD305%2F09%2FH008" target="_blank" >GD305/09/H008: Preparation, biotransformation, and optimalization of compounds with antitumor and antimicrobial effects</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Glycobiology

ISSN

0959-6658

e-ISSN

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Volume of the periodical

20

Issue of the periodical within the volume

11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

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UT code for WoS article

000282750300009

EID of the result in the Scopus database

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