AVENUES OF THE CONTEMPORARY GLYCOSCIENCE: FROM GLYCOMIC TECHNOLOGIES TO DRUGS THAT ARE SWEET INSIDE AS WELL AS AT THE SURFACE

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F10%3A10109497" target="_blank" >RIV/00216208:11310/10:10109497 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
AVENUES OF THE CONTEMPORARY GLYCOSCIENCE: FROM GLYCOMIC TECHNOLOGIES TO DRUGS THAT ARE SWEET INSIDE AS WELL AS AT THE SURFACE
Original language description
Introduction:Changes in cell surface glycosylation accompanies diseases such as inflammation, rheumatoid arthritis, and malignant transformations. These changes are supposed to be monitored by carbohydrate receptors of lectin type on the surface of cellsof the immune system. However, the exact nature of these receptors orchestrating such reactions remains elusive. Methods: We used a panel of recombinant lectin-like receptors of killer lymphocytes, bioaffinity techniques, oligosaccharide arrays, and mass spectrometry to analyze the complete oligosaccharide profiles responsible for sensitivity of tumor cells for natural killing and apoptosis. Results: Highly branched N-linked oligosaccharides recognized by NKR-P1 and NKG2D receptors were linked to sensitivity to natural killing. On the other hand, clustered O-linked oligosaccharides cross-linking CD69 receptors were able to cause the apoptotic death of the activated killer lymphocytes. Conclusions: We were able to identify classes of su
Czech name
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Czech description
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Project
<a href="/en/project/GD305%2F09%2FH008" target="_blank" >GD305/09/H008: Preparation, biotransformation, and optimalization of compounds with antitumor and antimicrobial effects</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of the 6th international conference on polysaccharides-glycoscience
ISBN
978-80-86238-78-4
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
5-8
Publisher name
Czech chemical society
Place of publication
Novotného Lávka 5, Prague, CZECH REPUBLIC
Event location
Prague, CZECH REPUBLIC
Event date
Sep 29, 2010
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000287421800001

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