HLA class II, MICA and PRL gene polymorphisms: the common contribution to the systemic lupus erythematosus development in Czech population

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10080388" target="_blank" >RIV/00216208:11310/11:10080388 - isvavai.cz</a>

Alternative codes found

RIV/00023728:_____/11:#0001007 RIV/00216208:11120/11:00003157

Result on the web

<a href="http://dx.doi.org/10.1007/s00296-010-1431-4" target="_blank" >http://dx.doi.org/10.1007/s00296-010-1431-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00296-010-1431-4" target="_blank" >10.1007/s00296-010-1431-4</a>

Result language

angličtina

Original language name

HLA class II, MICA and PRL gene polymorphisms: the common contribution to the systemic lupus erythematosus development in Czech population

Original language description

The genetic components contribute to the systemic lupus erythematosus development. This study for the first time determined the distribution of the polymorphisms and linkage disequilibrium in HLA class II, MICA and PRL gene among patients suffering fromSLE and healthy Czech individuals. DNA was obtained from the peripheral blood cells of 123 SLE patients and 96 healthy people. Allele variants of the HLA class II, MICA transmembrane polymorphism and PRL extrapituitary promoter -1149G/T SNP were detectedusing the sequence-specific primers analysis, PCR-fragment analysis and PCR-RFLP, respectively. In Czech population, only DRB1*03-DQB1*0201 haplotype is significantly associated with increased risk for SLE development: the frequency in SLE group was 44.7% in comparison with 15.2% in controls, P (c) { 0.0001; OR 4.54 CI 95% (2.36-9.09). The MICA-A5.1 allele is present significantly more often in SLE (55.7%) than controls (39.9%), P (c) = 0.005; OR 1.88 CI 95% (1.29-2.77), and the combina

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

—

Project

<a href="/en/project/NS10618" target="_blank" >NS10618: The role of the prolactin gene polymorphism and its expression in peripheral mononuclear cells in the autoimmune diseases pathogenesis ? systemic lupus erythematosus, inflammatory joint diseases (psoriatic and rheumatoid arthritis) and psoriasis vulgaris</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Rheumatology International

ISSN

0172-8172

e-ISSN

—

Volume of the periodical

31

Issue of the periodical within the volume

9

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

1195-1201

UT code for WoS article

000294360700012

EID of the result in the Scopus database

—