Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10104227" target="_blank" >RIV/00216208:11310/11:10104227 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1524/ract.2011.1869" target="_blank" >http://dx.doi.org/10.1524/ract.2011.1869</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1524/ract.2011.1869" target="_blank" >10.1524/ract.2011.1869</a>
Alternative languages
Result language
angličtina
Original language name
Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals
Original language description
Scandium isotopes ((44)Sc, (47)Sc) are more available and their properties are convenient for either PET imaging or radiotherapy. To use them in nuclear medicine, ligands forming complexes with a high stability are necessary. Available experimental dataon stability constants for complexes of ligands such as EDTA, DTPA, DOTA, NOTA and TETA with various metal ions have been published. But scandium is the exception since scarce data is available in the literature. Values of stability constants of Sc(III)with the ligands were determined by free-ion selective radiotracer extraction, complemented by (45)Sc NMR and potentiometry data. The thermodynamic stability of the Sc-complexes increases in the order TETA { NOTA { EDTA { DTPA { DOTA. The in vitro stability of the Sc(III) complexes was studied in the presence of hydroxyapatite and rat serum to estimate their in vivo stability. The most stable complex was shown to be Sc-DOTA.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/MEB021041" target="_blank" >MEB021041: Scandium complexes with polydentate ligands as potential radiopharmaceuticals</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Radiochimica Acta
ISSN
0033-8230
e-ISSN
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Volume of the periodical
99
Issue of the periodical within the volume
10
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
653-662
UT code for WoS article
000296081600007
EID of the result in the Scopus database
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