Thermodynamic and Kinetic Study of Scandium(III) Complexes of DTPA and DOTA: A Step Toward Scandium Radiopharmaceuticals

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10272016" target="_blank" >RIV/00216208:11310/14:10272016 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/chem.201402041" target="_blank" >http://dx.doi.org/10.1002/chem.201402041</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/chem.201402041" target="_blank" >10.1002/chem.201402041</a>

Result language
angličtina
Original language name
Thermodynamic and Kinetic Study of Scandium(III) Complexes of DTPA and DOTA: A Step Toward Scandium Radiopharmaceuticals
Original language description
Diethylenetriamine-N, N,N',N '',N ''-pentaacetic acid (DTPA) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) scandium(III) complexes were investigated in the solution and solid state. Three Sc-45 NMR spectroscopic references suitablefor aqueous solutions were suggested: 0.1m Sc(ClO4)3 in 1m aq. HClO4 (?Sc = 0.0 ppm), 0.1M ScCl3 in 1M aq. HCl (?Sc = 1.75 ppm) and 0.01M [Sc(ox)4](5-) (ox2- = oxalato) in 1M aq. K2C2O4 (?Sc = 8.31 ppm). In solution, [Sc-(dtpa)](2-) complex (?Sc = 83 ppm, ?nu = 770 Hz) has a rather symmetric ligand field unlike highly unsymmetrical donor atom arrangement in [Sc(dota)](-) anion (?Sc = 100 ppm, ?nu = 4300 Hz). The solid-state structure of K-8[Sc-2(ox)7] BULLET OPERATOR 13H2O contains two [Sc(ox)3](3-) units bridged by twice "side-on" coordinated oxalate anion with Sc3+ ion in a dodecahedral O-8 arrangement. Structures of [Sc(dtpa)](2-) and [Sc(dota)]- in [(Hguanidine)](2)[Sc(dtpa)] BULLET OPERATOR 3H2O and K[Sc(dota)][H6dota]-Cl-2 BULLET
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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