Eukaryotic pyruvate formate lyase and its activating enzyme were acquired laterally from a firmicute

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10105549" target="_blank" >RIV/00216208:11310/11:10105549 - isvavai.cz</a>
Result on the web
<a href="http://mbe.oxfordjournals.org/content/early/2011/02/03/molbev.msr032.full.pdf+html" target="_blank" >http://mbe.oxfordjournals.org/content/early/2011/02/03/molbev.msr032.full.pdf+html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/molbev/msr032" target="_blank" >10.1093/molbev/msr032</a>

Result language
angličtina
Original language name
Eukaryotic pyruvate formate lyase and its activating enzyme were acquired laterally from a firmicute
Original language description
Most of the major groups of eukaryotes have microbial representatives that thrive in low oxygen conditions. Those that have been studied in detail generate ATP via pathways involving anaerobically functioning enzymes of pyruvate catabolism that are typically absent in aerobic eukaryotes and whose origins remain controversial. Pyruvate formate lyase (Pfl) catalyzes the non-oxidative generation of formate and acetyl-Coenzyme A (CoA) from pyruvate and CoA and is activated by Pfl activating enzyme (Pfla). To clarify the origins of this pathway, we have comprehensively searched for homologs of Pfl and Pfla in publicly available large-scale eukaryotic genomic and cDNA sequencing data, including our own from the anaerobic amoebozoan Mastigamoeba balamuthi. Surprisingly, we find that these enzymes are widely distributed, and are present in diverse facultative or obligate anaerobic eukaryotic representatives of the archaeplastidan, metazoan, amoebozoan, and haptophyte lineages. Using maximum li
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)