Shh Expression in a Rudimentary Tooth Offers New Insights Into Development of the Mouse Incisor

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10105754" target="_blank" >RIV/00216208:11310/11:10105754 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/11:00364584 RIV/68378050:_____/11:00364584

Result on the web

<a href="http://dx.doi.org/10.1002/jez.b.21408" target="_blank" >http://dx.doi.org/10.1002/jez.b.21408</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jez.b.21408" target="_blank" >10.1002/jez.b.21408</a>

Result language

angličtina

Original language name

Shh Expression in a Rudimentary Tooth Offers New Insights Into Development of the Mouse Incisor

Original language description

For teeth as for any organ, knowledge of normal development is essential for the proper interpretation of developmental anomalies in mutant mice. It is generally accepted that tooth formation is initiated with a single signaling center that, in the incisor region, is exclusively related to the development of the functional adult incisor. Here, using a unique combination of computer-aided three-dimensional reconstructions and whole mount in situ hybridization of mandibles from finely staged wild-type mouse embryos, we demonstrate that several Sonic hedgehog (Shh) expression domains sequentially appear in the lower incisor region during early development. In contrast to the single Shh expression domain that is widely assumed to be present in each lower incisor area at ED12.5-13.5, we identified two spatially distinct regions of Shh expression that appear in an anterior-posterior sequence during this period. The initial anterior, more superficially located Shh expression region represente

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution

ISSN

1552-5007

e-ISSN

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Volume of the periodical

316B

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

347-358

UT code for WoS article

000291699400005

EID of the result in the Scopus database

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