Ellipticine cytotoxicity to cancer cell lines - a comparative study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10106313" target="_blank" >RIV/00216208:11310/11:10106313 - isvavai.cz</a>

Alternative codes found

RIV/62156489:43210/11:00177572 RIV/00216208:11130/11:7258 RIV/00064203:_____/11:7258

Result on the web

<a href="http://www.intertox.sav.sk/ITX_pdf/04_02_2011/10102-Volume4_Issue_2-06_paper.pdf" target="_blank" >http://www.intertox.sav.sk/ITX_pdf/04_02_2011/10102-Volume4_Issue_2-06_paper.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/v10102-011-0017-7" target="_blank" >10.2478/v10102-011-0017-7</a>

Result language

angličtina

Original language name

Ellipticine cytotoxicity to cancer cell lines - a comparative study

Original language description

Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action. This anticancer agent should be considered a pro-drug, whose pharmacological efficiency and/or genotoxic side effects are dependent on its cytochrome P450 (CYP)- and/or peroxidase-mediated activation to species forming covalent DNA adducts. Ellipticine can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Here,a comparison of the toxicity of ellipticine to human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neu- roblastoma IMR-32, UKF-NB-3 and UKF-NB-4 cells and U87MG glioblastoma cells and mechanisms of its action to these cells wereevaluated. Treatment of all cells tested with ellipticine resulted in inhibition of cell growth and proliferation. This effect was associated with formation of two covalent ellipticine-derived DNA adducts, identical to those formed by 13-

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Interdisciplinary toxicology

ISSN

1337-6853

e-ISSN

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Volume of the periodical

4

Issue of the periodical within the volume

2

Country of publishing house

SK - SLOVAKIA

Number of pages

8

Pages from-to

98-105

UT code for WoS article

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EID of the result in the Scopus database

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