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Medicinal Application of Carboranes Inhibition of HIV Protease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10099103" target="_blank" >RIV/00216208:11310/12:10099103 - isvavai.cz</a>

  • Alternative codes found

    RIV/61388980:_____/12:00376636 RIV/61388963:_____/12:00376636

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Medicinal Application of Carboranes Inhibition of HIV Protease

  • Original language description

    The aspartic protease of the human immunodeficiency virus is one of the most extensively studied enzymes known to man. More than 200 X-ray structures of the protein in the presence or absence of ligands or inhibitors have been determined to date, and thesymmetric depictions of this dimeric enzyme have become one of the icons of modern structural biology. The HIV protease is crucial for the production of infectious viral particles, and PR inhibitors are potent and specific anti HIV drugs. The successfulrational design of HIV PIs is one of the most striking examples of structure-based drug design. In this chapter, we will explain why the design of novel, potent PIs is still urgently needed and that derivatives of bis(dicarbollide)(1-) ion [(1,2-C2B9H11)-3,3'-Co(III)](1-), a compound well known to the carborane community, act as unexpected class of specific HIV PIs. We shall review their activity, specificity, mechanism of action, and binding mode to HIV protease

  • Czech name

  • Czech description

Classification

  • Type

    C - Chapter in a specialist book

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Book/collection name

    Boron Science - New Technologies and Applications

  • ISBN

    978-1-4398-2662-1

  • Number of pages of the result

    30

  • Pages from-to

    41-70

  • Number of pages of the book

    850

  • Publisher name

    CRC Press Taylor & Francis Group

  • Place of publication

    Boca Raton

  • UT code for WoS chapter