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Unorthodox Inhibitors of HIV Protease: Looking Beyond Active-site-directed Peptidomimetics

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10286875" target="_blank" >RIV/00216208:11310/14:10286875 - isvavai.cz</a>

  • Alternative codes found

    RIV/61388963:_____/14:00429970

  • Result on the web

    <a href="http://dx.doi.org/10.2174/13816128113199990634" target="_blank" >http://dx.doi.org/10.2174/13816128113199990634</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2174/13816128113199990634" target="_blank" >10.2174/13816128113199990634</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Unorthodox Inhibitors of HIV Protease: Looking Beyond Active-site-directed Peptidomimetics

  • Original language description

    HIV protease (PR) is a key target for antiviral drugs, and HIV protease inhibitors (PIs) are a prime example of successful structure-based drug design. PIs show clear therapeutic benefits, but their efficacy can be compromised by poor bioavailabilitity,unwanted side effects, and most importantly, development of antiviral drug resistance. Therefore, the quest for novel, highly active compounds with improved resistance profiles, better pharmacokinetic properties, and fewer adverse effects continues. In particular, the problem of cross-resistance could be circumvented by identifying novel compounds that show different binding modes to HIV PR than the current clinical inhibitors.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GAP207%2F11%2F1798" target="_blank" >GAP207/11/1798: HIV protease inhibitors: mechanism of action and resistance development</a><br>

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Current Pharmaceutical Design

  • ISSN

    1381-6128

  • e-ISSN

  • Volume of the periodical

    20

  • Issue of the periodical within the volume

    21

  • Country of publishing house

    AE - UNITED ARAB EMIRATES

  • Number of pages

    9

  • Pages from-to

    3389-3397

  • UT code for WoS article

    000337899300002

  • EID of the result in the Scopus database