Unorthodox Inhibitors of HIV Protease: Looking Beyond Active-site-directed Peptidomimetics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10286875" target="_blank" >RIV/00216208:11310/14:10286875 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/14:00429970
Result on the web
<a href="http://dx.doi.org/10.2174/13816128113199990634" target="_blank" >http://dx.doi.org/10.2174/13816128113199990634</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/13816128113199990634" target="_blank" >10.2174/13816128113199990634</a>
Alternative languages
Result language
angličtina
Original language name
Unorthodox Inhibitors of HIV Protease: Looking Beyond Active-site-directed Peptidomimetics
Original language description
HIV protease (PR) is a key target for antiviral drugs, and HIV protease inhibitors (PIs) are a prime example of successful structure-based drug design. PIs show clear therapeutic benefits, but their efficacy can be compromised by poor bioavailabilitity,unwanted side effects, and most importantly, development of antiviral drug resistance. Therefore, the quest for novel, highly active compounds with improved resistance profiles, better pharmacokinetic properties, and fewer adverse effects continues. In particular, the problem of cross-resistance could be circumvented by identifying novel compounds that show different binding modes to HIV PR than the current clinical inhibitors.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP207%2F11%2F1798" target="_blank" >GAP207/11/1798: HIV protease inhibitors: mechanism of action and resistance development</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Pharmaceutical Design
ISSN
1381-6128
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
21
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
9
Pages from-to
3389-3397
UT code for WoS article
000337899300002
EID of the result in the Scopus database
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