The expression of CD25, CD11b, SWC1, SWC7, MHC-II, and family of CD45 molecules can be used to characterize different stages of gamma delta T lymphocytes in pigs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10105038" target="_blank" >RIV/00216208:11310/12:10105038 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/12:00379094
Result on the web
<a href="http://dx.doi.org/10.1016/j.dci.2011.11.003" target="_blank" >http://dx.doi.org/10.1016/j.dci.2011.11.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.dci.2011.11.003" target="_blank" >10.1016/j.dci.2011.11.003</a>

Result language
angličtina
Original language name
The expression of CD25, CD11b, SWC1, SWC7, MHC-II, and family of CD45 molecules can be used to characterize different stages of gamma delta T lymphocytes in pigs
Original language description
The expression of selected molecules was chosen to study porcine gamma delta lymphocytes and their CD2/CD8 subsets in different lymphoid organs in vivo and in vitro. Results indicate that many gamma delta T cells can constitutively express CD25 and MHC-II and that the frequency of gamma delta T cells positive for CD25, CD11b, SWC1 and SWC7 can be increased by stimulation. A diversified TCRdelta repertoire was found inside CD25+, CD11b+, SWC1- and CD45RA- cells. Ontogenetic studies revealed various age and/or colonization dependency for expression of all studied molecules except of SWC7. Findings generally indicate that CD25 represent an activation molecule that probably marks a functionally distinct subsets, expression of CD11b is perhaps connected toearly functions of naive gamma delta T cells in the periphery, SWC1 is lineage specific marker, SWC7 may represent an activation molecule with intrinsic or transient expression, and the expression of CD45RA/RC most likely defines naive an
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—

Project
<a href="/en/project/GA524%2F07%2F0087" target="_blank" >GA524/07/0087: Development of peripheral gamma delta T lymhocytes in swine</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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