CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10105668" target="_blank" >RIV/00216208:11310/12:10105668 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/12:00377338 RIV/00023001:_____/12:00056476 RIV/00216208:11110/12:13228 RIV/60460709:41210/12:54501
Result on the web
<a href="http://physiolgenomics.physiology.org/content/44/2/173.long" target="_blank" >http://physiolgenomics.physiology.org/content/44/2/173.long</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1152/physiolgenomics.00083.2011" target="_blank" >10.1152/physiolgenomics.00083.2011</a>
Alternative languages
Result language
angličtina
Original language name
CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis
Original language description
CD36 fatty acid translocase plays a key role in supplying heart with its major energy substrate, long-chain fatty acids (FA). Previously, we found that the spontaneously hypertensive rat (SHR) harbors a deletion variant of Cd36 gene that results in reduced transport of long-chain FA into cardiomyocytes and predisposes the SHR to cardiac hypertrophy. In the current study, we analyzed the effects of mutant Cd36 on susceptibility to ischemic ventricular arrhythmias and myocardial infarction in adult SHR-Cd36 transgenic rats with wild type Cd36 compared to age-matched SHR controls. Using an open-chest model of coronary artery occlusion, we found that SHR-Cd36 transgenic rats showed profound arrhythmogenesis resulting in significantly increased duration oftachyarrhythmias (207+-48s vs. 55+-21s, P is lower then 0.05), total number of premature ventricular complexes (2623+-517 vs. 849+-250, P is lower then 0.05) and arrhythmia score (3.86+-0.18 vs. 3.13+-0.13, P is lower then 0.001). On the
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Genomics
ISSN
1094-8341
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
173-182
UT code for WoS article
000300048700007
EID of the result in the Scopus database
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