Manganese(II) Complexes as Potential Contrast Agents for MRI

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10119151" target="_blank" >RIV/00216208:11310/12:10119151 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/12:33142752
Result on the web
<a href="http://dx.doi.org/10.1002/ejic.201101336" target="_blank" >http://dx.doi.org/10.1002/ejic.201101336</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejic.201101336" target="_blank" >10.1002/ejic.201101336</a>

Result language
angličtina
Original language name
Manganese(II) Complexes as Potential Contrast Agents for MRI
Original language description
Mn2+ has five unpaired d electrons, a long electronic relaxation time, and labile water exchange, which make it an attractive alternative to Gd3+ in the design of contrast agents for medical Magnetic Resonance Imaging. In order to ensure in vivo safety and high contrast agent efficiency, the Mn2+ ion has to be chelated by a ligand that provides high thermodynamic stability and kinetic inertness of the complex and has to have at least one free coordination site for a water molecule. Unfortunately, thesetwo requirements are contradictory, as lower denticity of the ligands, which leads to more inner-sphere water molecules often implies a decreased stability of the complex, and, therefore, it is necessary to find a balance between both requirements. In the last decade, a large amount of experimental data has been collected to characterize the physico-chemical properties of Mn2+ chelates with variable ligand structures. They now allow for establishing trends of how the ligand structure, th
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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