Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2 '-C-methylribonucleosides, 2 '-deoxy-2 '-fluoroarabinonucleosides, arabinonucleosides and 2 '-deoxyribonucleosides
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10124072" target="_blank" >RIV/00216208:11310/12:10124072 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/12:00382173
Result on the web
<a href="http://dx.doi.org/10.1016/j.bmc.2012.07.003" target="_blank" >http://dx.doi.org/10.1016/j.bmc.2012.07.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bmc.2012.07.003" target="_blank" >10.1016/j.bmc.2012.07.003</a>
Alternative languages
Result language
angličtina
Original language name
Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2 '-C-methylribonucleosides, 2 '-deoxy-2 '-fluoroarabinonucleosides, arabinonucleosides and 2 '-deoxyribonucleosides
Original language description
A series of novel sugar-modified derivatives of cytostatic 7-hetaryl-7-deazaadenosines (2'-C-methylribonucleosides, 2'-deoxy-2'-fluoroarabinonucleosides, arabinonucleosides and 2'-deoxyribonucleosides) was prepared and screened for biological activity. Several examples of 2'-C-Me-ribonucleosides showed moderate anti-HCV activities in a replicon assay accompanied by cytotoxicity. Several 7-hetaryl-7-deazaadenine fluoroarabino- and arabinonucleosides exerted moderate micromolar cytostatic effects. However, all the sugar-modified derivatives were less active than the parent ribonucleosides.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GAP207%2F11%2F0344" target="_blank" >GAP207/11/0344: Combinatorial and rational approaches for the synthesis and evaluation of novel modified nucleosides with cytostatic and antimicrobial activity</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioorganic and Medicinal Chemistry
ISSN
0968-0896
e-ISSN
—
Volume of the periodical
20
Issue of the periodical within the volume
17
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
5202-5214
UT code for WoS article
000307828600015
EID of the result in the Scopus database
—