All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2 '-C-methylribonucleosides, 2 '-deoxy-2 '-fluoroarabinonucleosides, arabinonucleosides and 2 '-deoxyribonucleosides

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10124072" target="_blank" >RIV/00216208:11310/12:10124072 - isvavai.cz</a>

  • Alternative codes found

    RIV/61388963:_____/12:00382173

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.bmc.2012.07.003" target="_blank" >http://dx.doi.org/10.1016/j.bmc.2012.07.003</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.bmc.2012.07.003" target="_blank" >10.1016/j.bmc.2012.07.003</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2 '-C-methylribonucleosides, 2 '-deoxy-2 '-fluoroarabinonucleosides, arabinonucleosides and 2 '-deoxyribonucleosides

  • Original language description

    A series of novel sugar-modified derivatives of cytostatic 7-hetaryl-7-deazaadenosines (2'-C-methylribonucleosides, 2'-deoxy-2'-fluoroarabinonucleosides, arabinonucleosides and 2'-deoxyribonucleosides) was prepared and screened for biological activity. Several examples of 2'-C-Me-ribonucleosides showed moderate anti-HCV activities in a replicon assay accompanied by cytotoxicity. Several 7-hetaryl-7-deazaadenine fluoroarabino- and arabinonucleosides exerted moderate micromolar cytostatic effects. However, all the sugar-modified derivatives were less active than the parent ribonucleosides.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CC - Organic chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GAP207%2F11%2F0344" target="_blank" >GAP207/11/0344: Combinatorial and rational approaches for the synthesis and evaluation of novel modified nucleosides with cytostatic and antimicrobial activity</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Bioorganic and Medicinal Chemistry

  • ISSN

    0968-0896

  • e-ISSN

  • Volume of the periodical

    20

  • Issue of the periodical within the volume

    17

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    13

  • Pages from-to

    5202-5214

  • UT code for WoS article

    000307828600015

  • EID of the result in the Scopus database