Role of complement regulatory proteins CD46, CD55 and CD59 in reproduction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10125313" target="_blank" >RIV/00216208:11310/12:10125313 - isvavai.cz</a>

Result on the web

<a href="http://www.ivb.cz/folia/contents/Content_obsah.htm" target="_blank" >http://www.ivb.cz/folia/contents/Content_obsah.htm</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Role of complement regulatory proteins CD46, CD55 and CD59 in reproduction

Original language description

In humans, CD46 has been detected on the acrosomal membrane in sperm, in contrast to widespread surface expression on somatic cells where it plays a key role in the protection from complement attack. In rodents, CD46 is expressed solely on the acrosomalmembrane of mature sperm and their immediate precursors, spermatids. A monoclonal antibody against the short consensus repeat (SCR1) ectodomain of CD46 blocks binding of human sperm to zona-free oocytes in vitro. However, CD46-knockout mice are fertile and have an accelerated spontaneous acrosome reaction. Wild-caught field mice (Apodemus) also exhibit a rapid acrosome reaction and CD46 is not expressed in Apodemus sperm. CD46 may, therefore, play a role in stabilization of the acrosomal membrane. Two other complement regulatory proteins, CD55 and CD59, are localized on the plasma membrane of mammalian sperm. In human sperm, CD55 and CD59 are expressed also on the inner acrosomal membrane. It remains to be clarified what is the role of

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EG - Zoology

OECD FORD branch

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Project

<a href="/en/project/1M06011" target="_blank" >1M06011: The Centre of Molecular Methods for Monitoring the Diffuse Pollution of the Environment.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Zoologica

ISSN

0139-7893

e-ISSN

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Volume of the periodical

61

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

11

Pages from-to

84-94

UT code for WoS article

000304292800011

EID of the result in the Scopus database

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